Fiori, Stefano and Todisco, Elisabetta and Ramadan, Safaa and Gigli, Federica and Falco, Patrizia and Iurlo, Alessandra and Rampinelli, Cristiano and Croci, Giorgio and Pileri, Stefano A. and Tarella, Corrado (2021) HHV8-Negative Effusion-Based Large B Cell Lymphoma Arising in Chronic Myeloid Leukemia Patients under Dasatinib Treatment: A Report of Two Cases. Biology, 10 (2). p. 152. ISSN 2079-7737
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Abstract
Tyrosine kinase inhibitors (TKIs) are the treatment of choice for BCR-ABL1-positive chronic myeloid leukemia (CML). Although TKIs have substantially improved prognosis of CML patients, their use is not free of adverse effects. Dasatinib is a second generation TKI frequently associated with pleural effusion in up to 33% of patients. This results in symptoms as dyspnea, cough and chest pain that may require therapy discontinuation. In the present report, we describe two exceptional cases of HHV8-negative large B-cell effusion-based lymphoma (EBL) confined to the pleura, incidentally, diagnosed in patients presenting with dasatinib-related pleural effusion. One patient (case 1) is alive and is in remission at 17 months from large B-cell EBL diagnosis while unfortunately the other patient (case 2) died of progressive disease and COVID-19 pneumonia 16 months from large B-cell EBL diagnosis. These cases raise concern about a possible association between large B-cell EBL and dasatinib, and the different clinical outcome of the two cases poses a challenge in treatment decision. For this reason, we strongly recommend cytological investigation in patients with persistent/relapsing pleural effusion under dasatinib, primarily to validate its possible association with lymphoma development and to improve the knowledge about this entity.
Item Type: | Article |
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Subjects: | e-Archives > Biological Science |
Depositing User: | Managing Editor |
Date Deposited: | 03 Aug 2024 13:43 |
Last Modified: | 29 Jul 2025 03:50 |
URI: | http://studies.sendtopublish.com/id/eprint/453 |